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Pathophysiology refers to the functional changes that accompany various diseases and conditions, particularly as they relate to radiological imaging. It encompasses an understanding of the underlying mechanisms of disease processes, including cellular and molecular alterations, as well as how these changes manifest in tissues and organs. In the context of Radiology, pathophysiology is crucial for interpreting medical images and diagnosing conditions accurately. By recognizing the patterns of abnormalities associated with specific diseases and understanding the underlying pathophysiological processes, radiologists can provide valuable insights to guide patient care. Thus, Pathophysiology serves as a bridge between basic science concepts and clinical radiology practice, enabling healthcare providers to make informed decisions for their patients.