CategoryHierarchies.com

Linkage disequilibrium refers to the non-random association of alleles at different loci on the same chromosome. It arises when there is limited recombination between two genetic markers, resulting in the co-occurrence of specific allelic combinations more frequently than would be expected by chance. In the context of population genetics, linkage disequilibrium can provide valuable insights into historical events and demographic processes that have shaped gene frequencies within populations. It serves as a tool to identify genetic regions associated with phenotypic traits or disease susceptibility, allowing for fine-mapping and positional cloning studies in both model and non-model organisms. Additionally, linkage disequilibrium can inform evolutionary biologists about the role of selection, migration, and drift on population structure and the maintenance of genetic variation. Overall, understanding linkage disequilibrium is crucial for elucidating complex patterns of genome organization and variation in natural populations, providing a foundation to investigate functional consequences of genetic diversity and its adaptive potential.