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Theoretical Biology is a branch of biology that applies mathematical and computational models to understand complex biological systems, including those found in oncology. It employs principles from mathematics, physics, engineering and computer science to elucidate the emergent properties and behaviors of cells and tissues as they interact with each other during cancer development and progression. By integrating insights gained through theoretical modeling with experimental data, this field offers a unique perspective on understanding the fundamental mechanisms driving cancer, paving the way for novel therapeutic approaches.