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Physical chemistry is concerned with the macroscopic and microscopic properties of chemical systems and their transformation, blending elements from both physics and chemistry. It delves into understanding how physical phenomena affect chemical processes, and vice versa. In this context, it explores concepts that range from thermodynamics to quantum mechanics, providing a foundation for comprehending the principles governing biological macromolecules, nanostructures, and advanced materials—thus making it relevant to biotechnology as well. As such, physical chemistry fits seamlessly within the hierarchy of Science, Biotechnology, and Physics, elucidating the intricate relationship between these fields.